This study has revealed the IP inhibitor family as a promising anti-tubercular agent, targeting an essential component of the electron transport chain, QcrB. Due to the nature of the target, it is conceivable that the IP compounds could target both active and latent phases of TB infection, an important requirement of future anti-tubercular agents.…[Read more]

This study has revealed the IP inhibitor SCH772984 family as a promising anti-tubercular agent, targeting an essential component of the electron transport chain, QcrB. Due to the nature of the target, it is conceivable that the IP compounds could target both active and latent phases of TB infection, an important requirement of future…[Read more]

A PI induced accumulation of the CFTR precursor as observed in cultured human cells, was also observed with epoxomicin and MG-132 in our system. This may by itself not be sufficient for functional correction, but is likely show synergy with a suitable folding corrector and activator. Moreover, is seems likely that stabilisation of corrected human…[Read more]

This study has revealed the IP inhibitor family as a promising anti-tubercular agent, targeting an essential component of the electron transport chain, QcrB. Due to the nature of the target, it is conceivable that the IP compounds could target both active and latent phases of TB infection, an important requirement of future anti-tubercular agents.…[Read more]

The cytochrome bc1 complex or complex III of the electron transport chain is an integral membrane protein that forms a key component in the bacterial respiratory system. The complex functions as a ubiquinol-cytochrome C reductase, utilizing a catalytic core of three highly conserved components namely the cytochrome c1, cytochrome b and the Rieske…[Read more]

This study has revealed the IP inhibitor family as a promising anti-tubercular agent, targeting an essential component of the electron transport chain, QcrB. Due to the nature of the target, it is conceivable that the IP compounds could target both active and latent phases of TB infection, an important requirement of future anti-tubercular agents.…[Read more]

The cytochrome bc1 complex or complex III of the electron transport chain is an integral membrane protein that forms a key component in the bacterial respiratory system. The complex functions as a ubiquinol-cytochrome C reductase, utilizing a catalytic core of three highly conserved components namely the cytochrome c1, cytochrome b and the Rieske…[Read more]

HD is a lethal autosomal dominant neurodegenerative disease caused by expansion of a stretch of CAG-encoded glutamines near the N-terminus of huntingtin, a protein whose mutant form accumulates as nuclear and cytoplasmic inclusions in the brain of HD patients. The disease is a progressive disorder with severe psychiatric, cognitive, and motor…[Read more]

However, it is not possible to assess the levels of both HMW- and LMW-AGEs using any of the current approaches. Subjecting foods to heating results in the formation of various AGE molecules, with the types of AGEs produced depending on the heat treatment method employed and the food involved. Unfortunately, most previous studies only examined the…[Read more]

HD is a lethal autosomal dominant neurodegenerative disease caused by expansion of a stretch of CAG-encoded glutamines near the N-terminus of huntingtin, a protein whose mutant form accumulates as nuclear and cytoplasmic inclusions in the brain of HD patients. The disease is a progressive disorder with severe psychiatric, cognitive, and motor…[Read more]

HD is a lethal autosomal dominant neurodegenerative disease caused by expansion of a stretch of CAG-encoded glutamines near the N-terminus of huntingtin, a protein whose mutant form accumulates as nuclear and cytoplasmic inclusions in the brain of HD patients. The disease is a progressive disorder with severe psychiatric, cognitive, and motor…[Read more]

HD is a lethal autosomal dominant neurodegenerative disease caused by expansion of a stretch of CAG-encoded glutamines near the N-terminus of huntingtin, a protein whose mutant form accumulates as nuclear and cytoplasmic inclusions in the brain of HD patients. The disease is a progressive disorder with severe psychiatric, cognitive, and motor…[Read more]

Further, oleate prevented this drop in fatty acid oxidation and decreased palmitate uptake, which could decrease ceramide production by reducing the amount of palmitate present to be used in ceramide production. In fact, elevated ceramide levels accompany the palmitate- induced reduction in fatty acid oxidation in neonatal cardiac myocytes.…[Read more]

However, it is not possible to assess the levels of both HMW- and LMW-AGEs using any of the current approaches. Subjecting foods to heating results in the formation of various AGE molecules, with the types of AGEs produced depending on the heat treatment method employed and the food involved. Unfortunately, most previous studies only examined the…[Read more]

HD is a lethal autosomal dominant neurodegenerative disease caused by expansion of a stretch of CAG-encoded glutamines near the N-terminus of huntingtin, a protein whose mutant form accumulates as nuclear and cytoplasmic inclusions in the brain of HD patients. The disease is a progressive disorder with severe psychiatric, cognitive, and motor…[Read more]

The extracellular pathogen Yersinia, the vacuole-bound pathogen Chlamydia, and the cytosolic pathogen Listeria, all require HRI to efficiently complete their respective cellular infection cycles. A common denominator among these three pathogens is that they all require access to the infected cell cytosol: either for their virulence factors to…[Read more]

HD is a lethal autosomal dominant neurodegenerative disease caused by expansion of a stretch of CAG-encoded glutamines near the N-terminus of huntingtin, a protein whose mutant form accumulates as nuclear and cytoplasmic inclusions in the brain of HD patients. The disease is a progressive disorder with severe psychiatric, cognitive, and motor…[Read more]

However, it is not possible to assess the levels of both HMW- and LMW-AGEs using any of the current approaches. Subjecting foods to heating results in the formation of various AGE molecules, with the types of AGEs produced depending on the heat treatment method employed and the food involved. Unfortunately, most previous studies only examined the…[Read more]

Further, oleate prevented this drop in fatty acid oxidation and decreased palmitate uptake, which could decrease ceramide production by reducing the amount of palmitate present to be used in ceramide production. In fact, elevated ceramide levels accompany the palmitate- induced reduction in fatty acid oxidation in neonatal cardiac myocytes.…[Read more]

However, it is not possible to assess the levels of both HMW- and LMW-AGEs using any of the current approaches. Subjecting foods to heating results in the formation of various AGE molecules, with the types of AGEs produced depending on the heat treatment method employed and the food involved. Unfortunately, most previous studies only examined the…[Read more]