Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

The first plasmid lacks a protospacer specific to the T. gondii genome, and the Cas9 nuclease has been replaced with a pyrimethamine resistance cassette. The second plasmid only differs from the pU6- SAG1 plasmid in that it lacks the protospacer. All DNA transfections decreased the viability of parasites, although this effect was smallest in…[Read more]

The first plasmid lacks a protospacer specific to the T. gondii genome, and the Cas9 nuclease has been replaced with a pyrimethamine resistance cassette. The second plasmid only differs from the pU6- SAG1 plasmid in that it lacks the protospacer. All DNA transfections decreased the viability of parasites, although this effect was smallest in…[Read more]

Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

The first plasmid lacks a protospacer specific to the T. gondii genome, and the Cas9 nuclease has been replaced with a pyrimethamine resistance cassette. The second plasmid only differs from the pU6- SAG1 plasmid in that it lacks the protospacer. All DNA transfections decreased the viability of parasites, although this effect was smallest in…[Read more]

Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

Injury to the cerebellum is becoming increasingly recognized in preterm infants. Also in animal models, reduced number of neurons in cerebellum has been reported in the postnatal guinea-pig and fetal sheep following intrauterine growthrestriction. Moreover, a recent study found a diffuse pattern of cerebellar white matter damage in animals exposed…[Read more]

The first plasmid lacks a protospacer specific to the T. gondii genome, and the Cas9 nuclease has been replaced with a pyrimethamine resistance cassette. The second plasmid only differs from the pU6- SAG1 plasmid in that it lacks the protospacer. All DNA transfections decreased the viability of parasites, although this effect was smallest in…[Read more]

The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

The vulnerability of DKU80 strains to targeted double-strand breaks suggested we could perhaps rescue them through homologous recombination and, in the process, introduce desired point mutations. We observed that a 90 bp oligonucleotide homologous to the targeted region of PKG indeed improved the survival rate of DKU80 parasites transfected with…[Read more]

Endometriosis is a complex gynecological disease which occurs in 10% of reproductive age women. The disease is characterized by the presence and growth of endometrial tissue outside the uterus, causing pelvic pain, and infertility. The pathogenesis of endometriosis is not clearly defined. However, the disease is thought to be principally caused by…[Read more]

These observations can be compared with the results of a previous study in which we observed that intestinal morphological structures are also affected by CPF-exposure. We also found that CPF-exposure was associated with differences in protein expression in segments of the intestine. The immunohistochemical identification of claudin 4 seems to…[Read more]

These observations can be compared with the results of a previous study in which we observed that intestinal morphological structures are also affected by CPF-exposure. We also found that CPF-exposure was associated with differences in protein expression in segments of the intestine. The immunohistochemical identification of claudin 4 seems to…[Read more]

This lectin regulates cell-cell and cell-extracellular matrix interactions, cell AG-013736 customer reviews signaling, inflammatory responses and biological events, such as cellular activation, migration, differentiation, apoptosis and tumor metastasis. Moreover, galectin-3 acts as a powerful pro-inflammatory molecule to myeloid cells by inducing…[Read more]

These observations can be compared with the results of a previous study in which we observed that intestinal morphological structures are also affected by CPF-exposure. We also found that CPF-exposure was associated with differences in protein expression in segments of the intestine. The immunohistochemical identification of claudin 4 seems to…[Read more]