25. 26.44.45.27. 28.?46.47.29.30.48.31.49.32.50.?33.34.?51.35.52.Curr Osteoporos Rep (2015) 13:140?45 prostate cancer sufferers with bone metastases. J Manag Care Pharm. 2011;17:621?three. 53. Gartrell BA, Coleman RE, Fizazi K, et al. Toxicities following remedy with bisphosphonates and receptor activator of nuclear factor-kappaB ligand inhibitors in individuals with advanced prostate cancer. Eur Urol. 2014;65:278?six. 54. Allen MR, Burr DB. The pathogenesis of bisphosphonate-related osteonecrosis from the jaw: a great number of hypotheses, so couple of information. J Oral Maxillofac Surg. 2009;67:61?0. 55. Khan A, Morrison A, Hanley D, et al. Diagnosis and management of osteonecrosis with the jaw: a systematic critique and international consensus. J Bone Miner Res. 2014. Significant systematic review discussing osteonecrosis with the jaw following treatment with antiresorptive agents. 56.145 Demeestere I, Brice P, Peccatori FA, et al. Gonadotropin-releasing hormone agonist for j.addbeh.2012.ten.012 the prevention of chemotherapy-induced ovarian failure in sufferers with lymphoma: 1-year follow-up of a prospective randomized trial. J Clin Oncol. 2013;31:903?. 57. Yang B, Shi W, Yang J, et al. Concurrent remedy with gonadotropin-releasing hormone agonists for chemotherapyinduced ovarian harm in premenopausal women with breast cancer: a meta-analysis of randomized controlled trials. Breast. 2013;22:150?. 58. Song G, Gao H, Yuan Z. Effect of leuprolide acetate on ovarian function just after cyclophosphamide-doxorubicin-based chemotherapy in premenopausal sufferers with breast cancer: final results from a phase II randomized trial. Med Oncol. 2013;30:667.Safety and Safety The paradigm of new technologies as social experiments (henceforth NTaSE) deals with accountable deployment of technologies that might have undesirable side-effects. The idea is the fact that it truly is not possible to identify all prospective complications inside the design stage, and that it may as a result be essential to subject society to a deployment experiment with uncertain outcomes. Therefore far, the uncertain PD325901 chemical information outcomes addressed within the NTaSE-paradigm happen to be largely safety-related (nuclear waste and accidents, overall health effects of nanoparticles, genetically modified crops and so on.). Safety implies that possible harm is triggered by the design and style plus accidental events in the atmosphere, which include natural disasters and human jir.2012.0142 errors. What the paradigm has not covered so far are so-called adversarial dangers. These are dangers that are not caused by probabilistic natural events or accidents, even human failures, but rather by the determined, strategic behaviour of an adversarial agent. This is normally labelled safety as opposed to security. Essentially the most clear instance in the NTaSE literature of a technology with a security component is nuclear technologies: adversaries who get hold of nuclear material may possibly use it for weapons. Lately, Lehtveer and Hedenus (2015) discussed this extensively with regards to nuclear proliferation. Where the NTaSE-literature has discussed nuclear technology, it has focused on accidents (security), and has not addressed this adversarial perspective (security). As an example, Krohn and Weingart (1987) explicitly concentrate on the “accident as implicit experiment”, analysing the Chernobyl Meltdown, and in the similar vein, Van de Poel (2011) analyses the Fukushima accident.