O resolve the optimization models. Additional file five: Contains population info to calculate the incidence price by race/ethnicity who are above or beneath 2 occasions the S (The P3 ERP element). Adapted with permission from van Gaal federal poverty level. Further file six: Provides Cystic Fibrosis care center places and simulated patient places and demands that this short article used to carry out the case study. Abbreviations 2SFCA: Two-step floating catchment location; E2SFCA: Enhanced two-step floating catchment region; M2SFCA: Modified two-step floating catchment region; CF: Cystic fibrosis. Competing interests The authors declare that they have no competing interests. Authors’ contributions ZL participated within the style with the study, implemented the computational model and information analysis, and drafted the manuscript. NS and JLS carried out the study style and coordination and participated in data analysis. All authors contributed to interpretation of findings, preparing the manuscript, read and authorized the final manuscript. Authors’ information Zihao Li is an Operations Analysis Ph.D. student inside the College of Industrial and Method Engineering (ISyE) at Georgia Institute of Technology (GT). Dr. Nicoleta Serban may be the Coca-Cola Associate Professor in the College of ISyE at GT. She received her B.S. in Mathematics and an M.S. in Theoretical Statistics and Stochastic Processes from the University of Bucharest. She went on to earn her Ph.D. in Statistics at Carnegie Mellon University. In 2010, she was granted the NSF Profession award for analysis in service equity and access. Her researchrecord is fairly diverse, from mathematical statistics to modeling to data evaluation to qualitative insights on causality and complexity. Dr. Serban’s research interests on Well being Analytics span a variety of dimensions which includes large-scale data representation having a concentrate on processing patient-level overall health details into information options dictated by different considerations, for instance data-generation procedure and information sparsity; machine learning and statistical modeling to obtain knowledge from a compilation of health-related datasets having a focus on geographic and temporal variations; and integration of statistical estimates into informed choice creating in healthcare delivery and into managing the complexity with the healthcare method. Dr. Julie Swann would be the Harold R. and Mary Anne Nash Professor inside the College of ISyE at GT. She can also be a co-founder and co-director from the Wellness and Humanitarian Systems Center at GT. She received her B.S. in Industrial Engineering from GT in 1996 and her Ph.D. in Industrial Engineering and Management Sciences from Northwestern in 2001. In 2009?010 she was on loan towards the Centers for Illness Handle and Prevention (CDC) as a Senior Science Advisor for the H1N1 pandemic response to advise and evaluate the logistics of vaccine and medical countermeasures distribution to shield the American public. Her investigation specializes in provide chain management (specifically humanitarian networks) and wellness systems. Her investigation methods have focused on integrating optimization models with financial ideas associated to decentralized agents and on collaborating with other 164027512453468 disciplines to solve difficulties in well being policy. Dr. Swann was awarded the NSF career award in 2004 and 2014. Acknowledgments journal.pone.0169185 The authors thank Michael S. Schechter for supplying information with the current well being network on the disease as well as the Cystic Fibrosis Foundation for supplying the place of care centers.