Added file five: Contains population details to calculate the incidence price by race/ethnicity that are above or under two occasions the federal poverty level. Added file 6: Offers Cystic Fibrosis care center areas and simulated patient places and demands that this article used to carry out the case study. Abbreviations 2SFCA: Two-step floating catchment area; E2SFCA: Enhanced two-step floating catchment area; M2SFCA: Modified two-step floating catchment area; CF: Cystic fibrosis. Competing interests The authors declare that they have no competing interests. Authors’ contributions ZL participated in the design and style of the study, implemented the computational model and information evaluation, and drafted the manuscript. NS and JLS carried out the study design and style and coordination and participated in data analysis. All authors contributed to interpretation of findings, preparing the manuscript, read and approved the final manuscript. Authors’ data Zihao Li is definitely an Operations Analysis Ph.D. student within the School of Industrial and System Engineering (ISyE) at Georgia Institute of Technologies (GT). Dr. Nicoleta Serban is the Coca-Cola Associate Professor in the School of ISyE at GT. She received her B.S. in Mathematics and an M.S. in Theoretical Statistics and 11-DeoxojervineMedChemExpress Cyclopamine Stochastic Processes in the University of Bucharest. She went on to earn her Ph.D. in Statistics at Carnegie Mellon University. In 2010, she was granted the NSF Career award for study in service equity and access. Her researchrecord is quite diverse, from mathematical statistics to modeling to information analysis to qualitative insights on causality and complexity. Dr. Serban’s analysis interests on Wellness Analytics span numerous dimensions like large-scale data representation using a focus on processing patient-level wellness information into data features dictated by a variety of considerations, including data-generation course of action and data sparsity; machine finding out and statistical modeling to obtain information from a compilation of health-related datasets using a focus on geographic and temporal variations; and integration of statistical estimates into informed choice generating in healthcare delivery and into managing the complexity on the healthcare program. Dr. Julie Swann will be the Harold R. and Mary Anne Nash Professor in the College of ISyE at GT. She can also be a co-founder and co-director from the Wellness and Humanitarian Systems Center at GT. She received her B.S. in Industrial Engineering from GT in 1996 and her Ph.D. in Industrial Engineering and Management Sciences from Northwestern in 2001. In 2009?010 she was on loan for the Centers for Illness Handle and Prevention (CDC) as a Senior Science Advisor for the H1N1 pandemic response to advise and evaluate the logistics of vaccine and healthcare countermeasures distribution to safeguard the American public. Her analysis specializes in provide chain management (specially humanitarian networks) and health systems. Her research strategies have focused on integrating optimization models with financial concepts related to decentralized agents and on collaborating with other 164027512453468 disciplines to solve troubles in wellness policy. Dr. Swann was awarded the NSF career award in 2004 and 2014. Acknowledgments journal.pone.0169185 The authors thank Michael S. Schechter for giving understanding of the existing well being network in the illness and also the Cystic Fibrosis Foundation for offering the place of care centers. The study was supported by the National Science.