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  • Martha Hjelm posted an update 6 years, 5 months ago

    L Cardiol. 2009;54:2006?1. Subirana MT, Juan-Babot JO, Puig T, Lucena J, Rico A, Salguero M, et al. Particular Qualities of Sudden Death inside a Mediterranean Spanish Population. Am J Cardiol. 2011;107:622?. Muller D. How Sudden Is Sudden Cardiac Death? Circulation. 2006;114:1146?0. Marrugat J, Elosua R, Gil M. Sudden cardiac death epidemiology in Spain. Rev Esp Cardiol. 1999;52:717?5. Kannel WB, Gagnon DR, Cupples cid/civ672 LA. Epidemiology of sudden 890334415573001 coronary death: population at danger. Can J Cardiol. 1990;six:439?four. Fox CS. Temporal Trends in Coronary Heart Illness Mortality and Sudden Cardiac Death From 1950 to 1999: The Framingham Heart Study. Circulation. 2004;110:522?. genetics.115.182410 Sans S. Growing trends of acute myocardial infarction in Spain: the MONICA-Catalonia Study. Eur Heart J. 2004;26:505?5. Cobb LA, Fahrenbruch CE, Olsufka M, Copass MK. Altering Incidence of Out-of-Hospital Ventricular Fibrillation, 1980-2000. JAMA. 2002;288:3008?three. Myerburg RJ, Reddy V, Castellanos A. Ng behavior of mothers is larger for younger mothers than for Indications for Implantable Cardioverter-Defibrillators Based on Proof and Judgment. J Am Coll Cardiol. 2009;54:747?3.Meurer et al. Trials (2016) 17:373 DOI ten.1186/s13063-016-1493-zRESEARCHOpen AccessAttitudes and opinions regarding confirmatory adaptive clinical trials: a mixed approaches evaluation in the Adaptive Designs Accelerating Promising Trials into Remedies (ADAPT-IT) projectWilliam J. Meurer1,2*, Laurie Legocki3, Samkeliso Mawocha1, Shirley M. Frederiksen1, Timothy C. Guetterman3, William Barsan1, Roger Lewis4, Donald Berry5 and Michael FettersAbstractBackground: Adaptive styles happen to be increasingly used inside the pharmaceutical and device industries, but adoption inside the academic setting has been less widespread — particularly for confirmatory phase trials. We sought to understand perceptions about understanding, acceptability, and scientific validity of adaptive clinical trials (ACTs). Approaches: We utilised a convergent mixed methods design utilizing survey and mini-focus group information collection procedures to elucidate attitudes and opinions among “trial community” stakeholders with regards to understanding, acceptability, efficiency, scientific validity, and speed of discovery with adaptive designs. Information have been collected about numerous aspects of ACTs utilizing self-administered surveys (paper or Web-based) with visual analog scales (VASs) with no cost text responses and with mini-focus groups of essential stakeholders. Participants have been recruited as a part of an ongoing NIH/ FDA-funded investigation project exploring the incorporation of ACTs into an current NIH network that focuses on confirmatory phase clinical trials in neurological emergencies. “Trial community” representatives, namely, clinical investigators, biostatisticians, NIH officials, and FDA scientists involved within the organizing of four clinical trials, had been eligible to participate. Additionally, current and existing members of a clinical trial-oriented NIH study section have been also eligible. Final results: A total of 76 stakeholders completed the survey (out of 91 who were supplied it, response rate 84 ). Though the VAS attitudinal information showed substantial variability across respondents about acceptability and understanding of ACTs by a variety of constituencies, respondents perceived clinicians to be significantly less probably to know ACTs and that ACTs probably would raise the efficiency of discovery. Textual and concentrate group responses emerged into many themes that enhanced understanding of VAS attitudinal data like the following: acceptability of.