MiRs, and showed a Tubacin web substantial correlations with Gleason score. When the combination of six miRNAs (miR b and ) was employed, the AUC was significant in discriminating regular and tumor tissue . Spahn et al. analyzed samples from BPH, principal PCa of a high danger group and corresponding metastatic tissues by microarray analysis. A PCa distinct miRNA expression signature wasgenerated primarily based on the differential expression of (downregulated and upregulated) miRNAs among tumor and BPH tissues (p .). They observed a progressive downregulation of miR in aggressive and metastatic PCa. Downregulation of miR was also linked with Gleason score and clinical recurrence . Hagman et al. located the relative expression of miRc was drastically decrease in the PCa samples in comparison with the BPH samples and decreased with higher grade. The miRc level in sufferers with metastasis was located to be considerably decrease than sufferers with no metastasis . The expression of miRc distinguishes aggressive from nonaggressive PCa and was inversely correlated with PSA level. While there was no significant correlation between miRc expression levels and remedy response to therapy, the expression of miRc was drastically correlated with survival .Luu et al. BMC Urology :Web page ofTable Summary of miRNA expression research on prostate tumorserum samplesmiRNA investigated leta,leti,,p,a,,,,a,a,b,c,, a,,, a, a,a,,,, b,,, aa, a,a,,,,,,,,,,, leti,,a,,,b,,,b,b,a,a,,a,c , ,b,,,b,,b, c ,a,,,,,,a leta,letc,letf,b,a,,,b,b,a, b, ,a,c,,,b ,,, ,,,letc ,,b,,ap c a,,a,,,,p,, letb,,,,b,a,,,d,,a,,,,a,b, b,b, p,, a,,,,b, cb,,p,,p,,, leta,a,,a,b,, ,,,b,,,,dp,ap,cp, p,b, p,p,p b,a,b,,a,b,b,,c,,a,cp, a ,ap, b,a,b b,bp,b,a,b,c,,ap, b,,a, a,p,p,,,p,p,,,K,ULpb, p,p,pa,c,, a,b,a,b,a,b,c,a,a,b,a a,p,b, a, b, p,, a, b, b, b ,SNORD,Ub,U_s,U_x ,b,,,,p,bcp ,b Leta,,,b,a,b,,,,,c,,, a Expression up Tissue tumor Reference Volina, up up up up up up up up up up up up up up up up up up up up up uptumor tumor tumor serum prostate cells PCa cells tumor PCa cells PCa cells tumor tumor tumor plasma Prostate cells tumor serum plasma PCa cells plasma plasma tumor tumorPorkka, Ambs, Mercatelli, Mitchell, Mitchell, Mercatelli, Spahn, Wang, Khan, Szczyrba, Poliseno, Schaefer, Gonzales, Mihelich, Leite, Brase, Yaman Agaoglu, Hao, Shen, Bryant, Li, MartensUzunova, up up up uptumor serum tumor tumorWach, Nguyen, Larne, Walter, up up up up up up up up up up up uptumor tumor tumor tumor serum tumor tumor tumor serum serum PCa cells serumHe, Amankwah, Hudson, Tsuchiyama, Cheng, Lichner, Wang, CasanovaSalas Haldrup, Wang, Liang, Mihelich, Luu et al. BMC Urology :Web page ofTable Summary of miRNA expression studies on prostate tumorserum samples (Continued)letap,letdp,letdp,p,bp,ap,p,p, bp,dp, ap, bp, p,p,ap,, bp, p,p,p, bp,bp, bp, cp , p,p,p,,, p,p, p p,a,b,apa Leta,letb,letc,letd,let g,,a,b,a,,a,,a,b,,a, a,,, letb,,a,,,,a,a,,,,,,,, ,,,, h letbg, ab,ac,ae,ab,ab,, ab ,,a,b,a,e,,ap,b, , ap,,, ,,b,,,b,,,, c c c,,a,,a ,b,b,a,b,b,,,a,a,b,p,p,p,,, a,,,,b,b,b,,,,,,,p, p, p ,,p,p,p,p,b a p,cp,p,p,p , b,b,c,,d,ap,bp,,,p,,,,a, b, p, p,p,p,p p,, a,b a,cp,,,,b ap,p,bp,p,ap,bp,p,ap, ap, bp, ap, bp,ap,ap,cp,ep, ep, ap,ap,ap, ap,p, bp, bp, p,ap,p,p,p, p p,p, ap,bp,p, ap,ap, bp, p, p,p,p,p, p,p,p,p, pap,cp,p, a,p, p,p,p,p up tumor Kristensen, down down down down down down down down down down down downtumor tumor tumor tumor tumor tumor PCa cells Prostate cells plasma tumor tumor tumorPorkka, Ambs, Oz.