Om tropic regions, like Brazil, Cuba, Venezuela, and Chile, has been attracting a great deal consideration within the last years resulting from its distinct chemical profiles. Prenylated phenylpropanoids, prenylated p-coumaric acids, acetophenones, diterpenic acids, and caffeoylquinic acids have been shown to be incredibly prevalent and abundant in propolis from Brazil, primarily from the south-eastern area [9, 10, 21]. The flavonoids kaempferide and isosakuranetin and some amounts of kaempferol have been also discovered in Brazilian samples [32]. Also, red propolis from the northeast regions of Brazil presents higher concentrations of phenolic acids and the flavonoids formononetin, isoliquiritigenin, liquiritigenin, medicarpin, and biochanin A [33?5]. Cuban propolis includes a peculiar enrichment in polyisoprenylated benzophenones, additional particularly nemorosone, in addition to a minor content material of a mixture of xanthochymol and guttiferone E [9, 36] creating this sort of sample chemically distinct from both European and Brazilian propolis. Propolis from Venezuela is also composed of polyisoprenylated benzophenones additionally towards the usual constituents identified in samples of tropical regions [9, 37, 38]. Information and facts concerning the chemical composition of Australian propolis is very limited in spite of the wonderful biodiversity of the island. Propolis from Kangaroo Island is primarily composed of stilbenes, a number of them being prenylated. Moreover, it has also some prenylated cinnamic acids and flavonoids [39], like 2 ,3 ,four -trimethoxychalcone, 2 -hydroxy-3 ,4 -dimethoxychalcone, 2 ,4 -dihydroxy-3 -methoxychalcone, five,7-dihydroxy-2,3-dihydroflavonol 3-acetate (pinobanksin 3-acetate), and five,7-dihydroxy-6-methoxy-2,3dihydroflavonol 3-acetate [40]. Western Australian propolis is composed of Xanthorrhoeol, pterostilbene, sakuranetin, and pinostrobin [41]. Propolis of Australian stingless bees (Tetragonula carbonaria) is composed of C-methylated flavanones [42]. “Pacific” propolis (e.g., Okinawa, fnins.2014.00058 Taiwan, Hawaii, Indonesia, and Myanmar) is a different certain form of propolis. A brand new household of compounds, the prenylflavonoids, more specifically isonymphaeol-B, was identified in Okinawa propolis while three currently recognized compounds–nymphaeol-A, nymphaeol-B, and nymphaeol-C–have also4. Biological Properties and Therapeutic Activity of PropolisDespite propolis popularity more than time, it is actually not deemed as a therapeutic agent in traditional medicine because the standardization of chemical composition and biological activity is lacking. Such standardization is indispensable for acceptance in the well being technique. Thus, characterization of distinctive varieties of propolis according to its plant origin and corresponding chemical profile is mandatory. Research about propolis bioactivity have to start with chemical profiling with the extracts since that facts is crucial to have detailed and constant comparative data involving every typeTable 1: fnhum.2013.00596 Characteristic compounds of propolis from various geographic origins and respective plant supply.References [10, 20, 22] [9, 10, 32, 33] [32, 34, 35] [10, 180] [9, 36] [24, 25] [26] [27] [28?0] Plant supply Populus spp., a lot more predominantly P. nigra Common constituents (major elements) G007-LK site Pinocembrin, pinobanksin, chrysin, galangin, caffeic acid, ferulic acid, cinnamic acid, and their estersGeographic origin Europe, North America, New Zealand, and temperate zones of Asia Brazil Prenylated phenylpropanoids, phenolic acids, prenylated p-coumaric acids, acetophenones, diterpenic acids, caffeoylquinic a.